The Dec. 29, 1414, before the Bishop of Padua, the Bishop Pietro Marcello and other witnesses, Bonafari Baldo and his wife Sybil from Cetto declared they want to allocate part of their property to the construction of a church and monastery with a hospital in Santa Contrà Margaret, to be allocated to the Friars Minor.

Bonafari reserved the right to elect the rector of the hospital, which on his death would go to the College of Lawyers of the University of Padua.

The church in the parish of San Lorenzo at first caused some uncertainty; until the Bishop agreed to allow the work to continue.

At the beginning of the sixteenth century the church was enlarged in the direction of the architect Lorenzo da Bologna.

The church was now the subject of great works of tone evergetico that enriched the building especially in the sixteenth and seventeenth century.

Due to the Napoleonic suppressions the community of Friars Observant left the building and the convent in April 1810 and in the same year it became parish church organized by the secular clergy.

A connection between the various functions is the long porch on the street, with thirty-seven arches with terracotta decorations; those corresponding to the church and convent are twenty-six and supported by columns.

The portico, vaulted and decorated by the stories of St. Francis in "Verdeterra" (sort of grisaille) work of Francesco Squarcione executed between 1452 and 1466.

The aisles and long apse were enlarged to their present size in the late fifteenth century by Lorenzo da Bologna.