San Francesco d'Assisi all'Immacolata is a Roman Catholic church in the city of Catania, Sicily, southern Italy.

The construction of the first church at this site (1329) was promoted by Queen Eleanor of Anjou, wife of Frederick II of Aragon, and sister of the Franciscan friar and bishop, St Louis of Toulouse.

The apse has a fresco by Francesco Battaglia depicting St Francis praying at the Porziuncola.

Vincenzo Bellini was born adjacent to this church in the Palazzo Gravina-Cruyllas, now a civic museum dedicated to the composer.

[1] In front of the church is the Monument to Blessed Cardinal Giuseppe Dusmet.