They were based in San Francisco, California, and played their home games at Boxer Stadium.

PRO Rugby announced its second team, San Francisco, on November 19, 2015.

[1] Paul Keeler was announced in December 2015 as San Francisco's head coach.

[2] On December 15, 2016, PRO Rugby announced the immediate termination of the franchise due to a wide variety of issues, but mostly in regards to an unsuitable home venue and the inability to use Kezar Stadium.

[3] The squad for the 2016 PRO Rugby season:[4] Props Hookers Locks Loose forwards Scrum-halves Fly-halves Centers Wingers Fullbacks