San Francisco de Conchos is a town and seat of the municipality of San Francisco de Conchos, in the northern Mexican state of Chihuahua.

It was founded by Fray Alonso de la Oliva in 1604, and is the second oldest town in Chihuahua after Santa Bárbara.The town was named in honor of its patron saint, Saint Francis of Assisi, and the people of the Conchos tribe.

The name "Conchos" comes from the many small shells that were found in the river bed.

More than 4,000 people from various indigenous communities were at different times brought to live at the Mission San Francisco de Conchos.

In 1685, a Spanish presidio was founded at San Francisco de Conchos, in response to the Pueblo Revolt of 1680.