Saint George of the Genoese (Italian: San Giorgio dei Genovesi) is a Renaissance-style, Roman Catholic church located near the port of La Cala, on Via Buon Pastore in the ancient quarter of the Loggia, in Palermo, region of Sicily, Italy.

Before the construction of this church the Genoese community of Palermo celebrated its religious services in a chapel located in the complex of San Francesco d'Assisi.

[1] In 1576 the Genoese bought the little church of San Luca and the surrounding land, located near the port.

They demolished the old church and planned the construction of a new temple dedicated to their patron, Saint George.

To the north are is the dilapidated monument to the Obelisk for the 13 Victims dedicated to the revolutionaries shot near here by Bourbon authorities a month prior to the liberation by Garibaldi.