San Giovanni dei Lebbrosi is an ancient church in Palermo, Sicily.

While built by the Norman rulers, the architecture has strong Arabic influences.

The church was initially commissioned in 1071 by Robert Guiscard and Roger I of Sicily.

The leprosarium was putatively built because Roger II's brother died of Leprosy.

Over the years, the hospital and church was under the control of various religious orders, including the Teutonic knights.