San Girolamo is a 15th-century Roman Catholic church located in Spello, province of Perugia, region of Umbria, Italy.
The church and adjacent Franciscan monastery were built in 1472-1482 under the patronage of Braccio II Baglioni, then lord of Spello.
In 1965 the municipal government assigned the convent to a community of Piccoli Fratelli di p. C. de Foucault, who have since remained.
The church has a cross-shaped layout with a single nave flanked by lateral altars, ending in rounded apse.
The main altar sculpture in stucco depicts Saints John, Matthew, Mark, and Luke by a follower of Agostino Silva.