It was built by Mario Paniconi and Giulio Pediconi from 1960 to 1961, to serve a parish erected by Pope Pius XII in 1952.

Its roof is held up by 10 concrete piers, and is structurally independent of the walls, which end before they reach the roof (the empty space between them being filled with glass).

It is a parish church, served by Franciscans; in the crypt is a depiction of the Life of St Francis of Assisi in an unusual stone inlay technique.

The current Cardinal Priest of the Titulus Chiesa di San Gregorio VII is Cardinal Cleemis, the Major Archbishop of Trivandrum.

This article about a Roman Catholic church building in Italy is a stub.