San Gregorio della Divina Pietà is a small Roman Catholic church facing the Piazza Gerusalemme located in Rione Sant'Angelo, in Rome, Italy.

[1] San Gregorio was declared a parish church and remained so until 1729, although in the 16th century it lost almost all its territory due to the establishment of the nearby Ghetto.

[1] In 1729 the rectangular building was restored by Filippo Barigioni on behalf of Pope Benedict XIII, and given to the Congregation of the Operai della Divina Pietà (Workers of the Divine Mercy), founded in 1679 to help families once well off which had fallen into poverty—its modern appellation comes from that.

[3] Until 1870, the pope required the Jews living in the nearby ghetto to attend compulsory sermons (Italian: prediche coatte)[1] every sabbath in front of the church, which faced two gates of the Jewish quarter, but they avoided hearing them by putting wax in their ears.

[1] The interior is rectangular with one nave: painted on the vault, the Assunzione di Maria of Giuseppe Sereni; on the main altar, the Madonna della divina pietà of Gilles Hallet.