San Ignacio Church in Intramuros, Manila, Philippines, was designed for the Jesuits by architect Félix Roxas Sr., and completed in 1899.

The first church, designed by Italian Jesuit priest-architect Gianantonio Campioni, was constructed in 1587 and dedicated to St. Ignatius of Loyola.

[2] The second church, made of stone, was constructed from 1590 to 1596 following the plans of Antonio Sedeño and was dedicated to Saint Anne, the mother of the Virgin Mary.

[2] On September 6, 1852, an earthquake caused major damage to the façade of the church; the flanking bell towers and the lower floor of the nave were the only structures left standing.

The site later became a military barracks known as Cuartel de España, which served as the headquarters of the 31st American Infantry Regiment.

Located along Calle Arzobispo, within San Ignacio Church, its exhibits and 8,000 items of historical artifacts were extracted from Museo de Intramuros.

Its ruins were altered by the private developers, such as putting additional circular window holes on the building envelope.

However, its interiors are in the Renaissance Style with features such as arcaded and elevated galleries along the nave, a dark hardwood interior finish, an artesonado or coffered ceiling, fusion of bricks and piedra de Visayas or coral and limestone at the façade of the church, and pillars and outlines of portals and windows made up of white Carrara marble.

Besides the church, the headquarters of the Philippine Jesuit Mission (Casa Misión) was also spared, though partially damaged.

[9] When the Ateneo de Manila subsequently transferred to the newly built, Jesuit-owned San José Seminary on Padre Faura Street,[9] Ermita, the church became a parish.