San Juan Bautista (Spanish pronunciation: [saŋ ˈxwam bawˈtista]), capital of the Department of Misiones, Paraguay, is considered the cradle of the religious mission culture.

The city is the seat of the Roman Catholic Diocese of San Juan Bautista de las Misiones.

With a total area of 2,300 square kilometers, San Juan Bautista has a population of 18,441 inhabitants, 9,281 male and 9,161 female, according to projections of the General Office of Statistics, Surveys and Censuses.

This city was established during the government of Carlos Antonio López, declared a small town in 1893, and in 1945 was made the capital of the department.

Other interesting locations in the vicinity are: Beyond San Juan Bautista, an unpaved road goes to Santa María.