Santiago stands as an ancient city with roots as a Jesuit mission settlement, proudly retaining the timeless traits of its colonial past.

These include its expansive main square, the historically significant "house of the Indians", and a meticulously curated museum safeguarding colonial-era artworks.

In the colonial epoch, Santiago held a position of significance owing to its population, which flourished to approximately 3,000 inhabitants.

Throughout festive periods, the city orchestrated the grand spectacle of the Opera of Santiago, underscoring its cultural vibrancy and artistic fervor.

The city is surrounded by dense forests and agricultural land, with the Paraguayan Chaco to the west and the Paraná Plateau to the east.