San Juan Nepomuceno is a city and district in the Paraguayan department of Caazapá.

It lies 249 km southeast of the national capital city, Asuncion, at the terminus of the Blas Garay highway.

Blas Garay is a spur of the national highway Number 8 and forks at a crossroads near the town of Ñumí.

This district is located in the east of the department and shares borders with six districts of Caazapá (clockwise: N: General Higinio Morínigo, Abaí; E: Tavaí; S: Yuty; W: Buena Vista, Caazapá) and one of the Itapúa (Alto Verá).

Its total population is the third in the department, with 24,243 inhabitants, after Yuty and Abaí.