[3] San Luis was created into a municipality on June 15, 1968, when the barrios of San Luis, Santa Inez, Nuevo Trabajo, Cualision and Baylo were separated from the municipality of Esperanza and constituted into the new town, through Republic Act 5262.

[5] Since the 1970s, the town's economy has been largely based on logging industries.

According to the Philippine Statistics Authority, the municipality has a land area of 950.5 square kilometres (367.0 sq mi) [7] constituting 9.51% of the 9,989.52-square-kilometre- (3,856.98 sq mi) total area of Agusan del Sur.

[3] The population density was 37 inhabitants per square kilometre (96/sq mi).

Poverty Incidence of San Luis Source: Philippine Statistics Authority[14][15][16][17][18][19][20][21]