[5] The protected area of the Agusan Marsh Wildlife Sanctuary can also be reached in San Francisco thru the Barangays Caimpugan and New Visayas.

Due to the town's commendable folk arts and crafts made in stone, many scholars have suggested for its nomination in the UNESCO Creative Cities Network.

The opening of the Province of Agusan del Sur to most parts of Mindanao came during the government of President Ramon Magsaysay who ordered the first road survey to be conducted by the Department of Highway in 1952.

In early 1954, road construction began paving the way for the institution of public land subdivision and the in-migration of different local tribes and settlers from the various provinces of Mindanao, Visayas and Luzon.

As a result, the several barrios of San Francisco including Bayugan III, Wasi-an, Santa Cruz, Cabawan, Cabantao, Marfil and Tagbayagan were incorporated in the newly created municipality.

The barrios of Rizal, Ormaca, Mate and Karaos were later created and added to form final 27 barangays of the present day San Francisco.

Situated within the crossroad leading to other production centers in the region, San Francisco serves as the primary distribution point of goods and people for the province.

The presence of malls, hotels, restaurants, communication and transportation facilities makes San Francisco the training convention center of the province and a favored place for tourists to stay with Mount Magdiwata boosting its tourism sector.

Public Utility Van (PUV) also served San Francisco, bound for Davao, Butuan, Tandag, Mangagoy and Tagum.