San Manuel Colohete (Spanish pronunciation: [sam maˈnwel koloˈete]) is a municipality in the Honduran department of Lempira, located approximately twenty miles southwest of the departmental capital of Gracias.

The town is also on the route used by hikers coming from or going to hike nearby Celaque, the tallest mountain in Honduras, which dominates vistas around San Manuel.

In the census of 1887, it was a settlement of a village of "Concepcion Colohete" in Gracias municipality as it was now back then.

In the administration of Terencio Sierra, the municipality of "San Manuel Colohete" was created on 2 February 1901.

Its boundaries are: San Manuel Colohete is a very good place for coffee; due to its elevation from the sea level.