Talgua (Spanish pronunciation: [ˈtalɣwa]) is a municipality in the Honduran department of Lempira.

Talgua was founded in the colonial period in the place called "Las Mercedes" village.

In the administration of president Ramon Villeda Morales, on January 2, 1963, the capital was moved from Talagua to San Antonio de Pedernales.

The weather is hot because of the elevation from sea level and the vegetation, which consists of dry sub tropical forest.

Due to its elevation from sea level is not possible to have coffee plantations, therefore the main economic activities are beans and corn crops, followed by commerce of groceries and other home supplies.