It was originally attached to the most important female convent of the Benedictines in the city, Monastero Maggiore, which is now in use as the Civic Archaeological Museum.

The church today is used every Sunday from October to June to celebrate in the Byzantine Rite, in Greek according to the Italo-Albanian tradition.

[2] The church was completely rebuilt, starting in 1503, under the design of Gian Giacomo Dolcebuono in collaboration with Giovanni Antonio Amadeo.

[3] The interior has a vaulted nave separated by the division wall (the nuns followed the mass from a grating) and flanked by groin-vaulted chapels, which are surmounted by a serliana loggia.

Ippolita Sforza and her husband Alessandro Bentivoglio appear to be the main patrons of the decoration of the Renaissance church.

The dividing wall has frescoes depicting the Life of San Maurizio by Bernardino Luini which flank an altarpiece with an Adoration of the Magi by Antonio Campi.