San Nicola da Tolentino, or more in non-dialect known as the church Saint Niccolò da Tolentino, is a Roman Catholic church located on via Maqueda #157, between via dei Calderai and via Giardinaccio, at the Southwest border of the quarter of Kalsa (Tribunali) of the historic centre of Palermo, region of Sicily, Italy.

In 1507, under the approval of the archbishop of Palermo, Giovanni Paternò, the Clarissan nun, Lucrezia di Leo, obtained the site and adjacent courtyard to found a small monastery called Santa Maria del Popolo.

The Augustinian monastery was felt to be failing to keep their monastic orders, they were moved to Santa Maria della Sanita, and this church became a parish site of worship.

The first chapel on the right has a 1494 baptismal font with a statue of St John the Baptist derived from the nearby, now demolished church of San Giovanni dei Tartari.

[4] The church of San Nicolò alla Kalsa, also known as dei Latini, was located in Piazza Santo Spirito, near the Porta Felice.