The Río San Pedro is a river of Guatemala and Mexico.

Its sources are located in the Guatemalan department of El Petén at 17°08′05″N 89°54′10″W / 17.134803°N 89.902668°W / 17.134803; -89.902668 (Río San Pedro).

The river flows westwards until it reaches the Mexican border and crosses into the state of Tabasco at 17°16′47″N 90°59′16″W / 17.279636°N 90.987697°W / 17.279636; -90.987697 (Río San Pedro).

The Guatemalan part of the San Pedro river basin covers an area of 14,335 square kilometres (5,535 sq mi).

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