San Pedro de Mocama was part of the missions system of Spanish Florida, a territory of New Spain.
San Pedro was one of the earliest and most prominent missions of Spanish Florida, and its church was as big as the colonial one in St. Augustine.
San Pedro de Mocama, protected by an associated fort, was for a time at the northern extent of Spanish power, serving as a bulwark against the Guale people to the north.
Another source links this mission with San Pedro de Mocama, and dates its foundation to the arrival of Fray Lopez in 1587.
Some had learned to read and write in a combination of Spanish, Latin, and the system of writing the Timucua language devised by Father Francisco Pareja, who worked at the San Juan del Puerto mission, located at the mouth of the St. Johns River at present-day Fort George Island.