San Raffaele (also known as San Raffaele a Materdei or properly, Santi Raffaele e Margherita da Cortona) is a church on Via Amato di Montecassino, in the quartiere of Materdei in Naples, Italy.

The church was founded in 1759 built on designs of Giuseppe Astarita, adjacent to a hospice for women called a Ritiro delle Pentite, or hospice for prostitutes.

The interior has a highly decorated polychrome altar surmounted by a baldacchino of gilded wood with angels and a crown.

San Raffaele (St Raphael), the patron of fishermen, and often represented in paintings with fish.

The saint of this church was often revered by infertile couples.