San Rocco is a small Baroque-style, Roman Catholic church facing the Piazza dei Cavalieri in central Pisa, Italy.

In 1575, a near complete reconstruction occurred when the church was granted to the Company (Order) of Saint Roch (San Rocco).

The Order of St. Rocco was suppressed in 1782, and the church soon fell under the care of the diocese, and another restoration occurred in 1899.

The ceiling fresco of St Rocco protecting those affected with the plague is attributed to Francesco Venturi.

On the altar on the left nave is a canvas of St Rocco attributed to Giovanni Antonio Sogliani.