Sand Spring Run is a tributary of White Deer Creek in Union County, Pennsylvania, in the United States.

Sand Spring Run begins in a shallow valley on a mountain in Lewis Township.

[1] Sand Spring Run joins White Deer Creek 12.48 miles (20.08 km) upstream of its mouth.

[2] The mouth of the stream is in the United States Geological Survey quadrangle of Williamsport SE.

[8] Sand Spring Run was entered into the Geographic Names Information System on August 2, 1979.

[7] The Sugar Valley Railroad, which was incorporated on October 19, 1900, passed near Sand Spring Run.

[10] Wild trout naturally reproduce in Sand Spring Run in its lower 4.47 miles (7.19 km).