Sandy Island is the name of a small unincorporated community in Georgetown County, South Carolina, United States, and a larger island between the Pee Dee and Waccamaw Rivers that has been preserved as a refuge and nature center.

The northern part of the island is higher and is mostly a longleaf pine forest, which provides a refuge for the endangered red-cockaded woodpecker and numerous other species of plants and animals.

About 9,000 acres (36 km2) of the island has been purchased by The Nature Conservancy for permanent protection from development.

Because of its resources, the island is regularly visited by naturalists, planters, archaeologists and geologists.

Brookgreen Gardens runs daily "scenic" boat rides close to the island.