Andrews is a town in both Georgetown and Williamsburg counties in the U.S. state of South Carolina.

General aviation airfield Robert F. Swinnie Airport is 2 miles (3 km) east of its central business district.

U.S. Route 521 bypasses the town to the south, then passes through the west side of the town; the highway leads northwest 62 miles (100 km) to Sumter and east 17 miles (27 km) to Georgetown, the county seat.

According to the United States Census Bureau, Andrews has a total area of 2.2 square miles (5.7 km2), all land.

[citation needed] The towns of Rosemary and Harpers Crossroads were settled along the Georgetown and Western Railroad, which started operation in 1886.

In 1905, the Seaboard Air Line Railroad built a route through the town, along with a sizable maintenance shop.

During the 1920s, Andrews had the title of being the fastest growing town in the United States for its age.

[citation needed] When the Great Depression of the 1930s started, Andrews was hit hard, with population down by 700 when Seaboard scaled back its operations.

In 1932, the local economy was dealt a further blow when the Atlantic Coast Lumber Co. closed its nearby plant.

[citation needed] After World War II, the Andrews Development Board was incorporated to attract businesses to the area.