Sankt Leon-Rot is a municipality in the district of Rhein-Neckar-Kreis, in Baden-Württemberg, Germany.

It is situated 16 km south of Heidelberg.

Sankt Leon-Rot is located in the Kraichbach lowlands, belonging to the Upper Rhine Graben.

It is part of the Rhine-Neckar metropolitan region.

This Rhein-Neckar-Kreis location article is a stub.