Zuzenhausen is in the northern part of Kraichgau, about 8 km from Sinsheim in the Elsenz river valley.

The municipality is bordered to the north by Meckesheim, to the east by Eschelbronn, to the south by the city of Sinsheim, and to the west by Dielheim.

Speyer enfeoffed the Barons von Venningen at least partially since the 14th century and completely from 1637.

The lily staves are from the coat of arms of the barons of Venningen, who lorded over Zuzenhausen for hundreds of years.

Every two years Zuzenhausen celebrates the Dachsenfranzfest, a historical Volksfest in memory of Franzesko Regali, Dachsenfranz.