Sant'Ambrogio is the Roman Catholic mother church or chiesa matrice in the center of the town of Cerami, in the province of Enna, region of Sicily, Italy.

A church at this site, dedicated to St Ambrose, was likely implanted by the Norman conquerors of the 12th-century.

A larger church was initially built in 1455 and refurbished in the following centuries.

It houses a white marble Madonna and Child by Antonello Gagini.

It also has an 18th-century statues of St Michael Archangel by Filippo Quattrocchi of Gangi.