Sant'Angelo (officially Santa Maria degli Angeli) is a church in Milan, Lombardy, northern Italy, belonging to the Franciscan Order.

The church was constructed in the mid-16th century by the Spanish general and Governor Milan Ferrante Gonzaga, over an edifice already existing in 1418, in replacement of the eponymous one, which had been destroyed to build the new walls.

The triumphal arch has a frescoes with a solemn Incoronation of Mary by Stefano Maria Legnani (Legnanino).

In the transept is the tomb of Blessed Beatrice Casati, the wife and widow of Francino Rusca, the Earl of Locarno.

Her epitaph reads, “Here lies Beatrix, the shining jewel of the Rusca family, who was married to Count Francino.