Sant'Angelo a Nilo is a Roman Catholic church located on the Decumano Inferiore (Spaccanapoli street) in Naples, Italy.

Angel and Mark, by will of cardinal Rainaldo Brancacci, whose family had a palace nearby.

Remains of the original Catalan-Gothic structure include the main portal, with an architrave featuring angels, and a fresco in the lunette with The Virgin Mary and Saints Michael and Baculus with Cardinal Brancaccio (15th century).

Artworks in the interior include the tomb of cardinal Brancaccio, canvasses from Luca Giordano school, a 16th-century altarpiece by the Sienese painter Marco Pino and a marble tabernacle in the sacristy.

Antonio Valente, the first major keyboard composer of the Neapolitan school, was organist here in 1565–80.