Sant'Anna a Capuana is a church located on the piazza of the same name in Naples, Italy.

The church was founded in the 16th century near the former city gate at Porta Capuana, as a small chapel for the monks of the Convent of San Francesco di Paola.

Construction of the present structure dates from 1751, a design by Giuseppe Astarita.

The canvas in the cupola depicts the Holy Family with St Anne by Marco Cardisco.

The chapels were painted in the 18th century by Francesco Narici and Giovanni Cosenza.