Sant'Ansano is a neoclassical-style, Roman Catholic church located in the town of Spoleto, in the province of Perugia, region of Umbria, Italy.
A church at the site had been built around the tomb of St Isaac, a Syrian eremitic monk who supposedly came to a mountain around Spoleto in the 6th century.
The present church was built in the late 1700s by the Milanese architect Antonio Dotti.
Inside are housed a fresco depicting the Madonna and Child and two Saints by Giovanni di Pietro, also called Lo Spagna and a main altarpiece depicting the Martyrdom of St Ansano by Archita Ricci.
The crypt has romanesque-style, sculpted capitals (8-9th century) atop ancient Roman columns.