Sant'Antonio Abate is a Neoclassical-style Roman Catholic parish church located on Via Mazzini #2 in the town of Melilli, province of Siracusa, region of Sicily, Italy.
A church at this site with its adjacent monastery of the Order of Friars Minor (First order Franciscans) had been established by the early 15th century.
The church Once had a tall bell-tower with a clock.
The portal has 6 bronze bas-relief panels, depicting scenes from the life of the titular saint, sculpted by Domenico Girbino.
The lateral altars have wooden sculptures.