Sant'Antonio Abate (Saint Anthony the Abbot) is a Gothic-style Roman Catholic parish church located on Via Roma #203A in the ancient quarter of Castellammare, in central Palermo, region of Sicily, Italy.

In that era, the building was adjacent to the medieval walls of the city and was near the confluence of two streams or rivers, the Kemonia and Papireto.

In the 16th century, entrance to the church-yard was located west of Via Roma in the area now comprising Piazzetta Marchese Arezzo.

One modification present since the 18th century was the insertion of a wooden icon depicting the Christ devotion of Ecce Homo, a work attributed to Frate Umile from Petralia.

In 1733, the church that was already the parish of the Senate received the honor of proclaiming the Ecce Homo as the ordinary patron of the city.

The main 17th-century altarpiece depicts San Carlo Borromeo in procession painted by Giuseppe Salerno.