Sant'Antonio di Padova is a Gothic-style, Roman Catholic parish church located on via Vittorio Emanuele in central Acireale in the region of Sicily of Italy.
A church at the site was built after the plague of 1466, and dedicated to St Sebastian.
When a new onslaught of the plague afflicted the town late in the next century, a new church was commissioned.
The present church with a single nave houses frescoes started by Pietro Paolo Vasta.
In 1755, while frescoing the central nave with the Glory of St. Anthony he was afflicted with a stroke.