Santa Ana is the original municipal center of Taguig from its establishment in 1587, during the Spanish colonization of the Philippines.

The Archdiocesan Shrine of St. Anne is a Roman Catholic church located in the barangay.

Built in 1587, it is situated next to the Taguig River and across Plaza Quezon, where the statue of Manuel L. Quezon was erected when he was still serving as the nation's President.

Its Gabaldon Building, which has remained standing since it was constructed from 1917 to 1928 and currently serves as the school's museum.

[4] Santa Ana is bounded to the north by Tuktukan, to the east by Calzada Tipas, to the south by Laguna de Bay, and to the west by the Taguig River.