The mission of Santa Ana was founded in 1755 by Julian Knogler.

[1][2] Santa Ana is the central town of Cantón Santa Ana and is located in the San Ignacio de Velasco Municipality, José Miguel de Velasco Province.

The town is situated at an elevation of 464 m in the Chiqitanía region between Santa Cruz capital and the Brazilian border.

The population of the place has increased rapidly over the past two decades: Today, Camba Spanish is the most commonly used everyday language.

[7] In the past, various dialects of Otuke, such as Covareca and Curuminaca, were spoken at the mission of Santa Ana.