San Ignacio de Zamucos or San Ignacio was a Jesuit mission in Santa Cruz Department, Bolivia that was founded in 1724 and abandoned in 1745.

The ruins of San Ignacio de Zamucos are located in the southeastern end of the Kaa-Iya del Gran Chaco National Park, near San Ignacio in Cordillera Province, Santa Cruz Department.

[2][3] In 1724, San Ignacio de Zamucos was founded in indigenous Ayoreo ("zamucos ugaraños") territory by the Jesuit missionary Agustín Castañares and the friar Ignacio Chomé, as well as Felipe Suárez and Juan Bautista Zea.

However, when Castañares died and the mission was attacked, it was abandoned in 1745.

Most of the mission's inhabitants then went on to form part of the population of San Ignacio de Velasco.