Santa Bernardina is a suburb of Durazno, the capital city of Durazno Department, in central Uruguay.

This suburb is located to the north of the city of Durazno, across the river Río Yí.

Directly east of the suburb is the Santa Bernardina International Airport.

In 2011, Santa Bernardina had a population of 1,094.

This article about a place in Durazno Department is a stub.