Santa Chiara is a church in the rione Pigna, formerly the Campus Martius area of Rome dedicated to Saint Clare of Assisi.

It was founded by Saint Charles Borromeo, who built a Franciscan convent (now used by the Pontifical French Seminary) and the church within the ruins of the Baths of Agrippa in 1592.

In 1883, the Congregation of the Holy Spirit acquired the property, and rebuilt the church, giving it a new facade designed by Luca Carimini in 1888.

On the lower of the two levels, the main door is framed by two columns holding a semicircular tympanum with a decorated lunette.

Below the windows is the Latin inscription: "DEO OPTIMO MAXIMO IN HONOREM IMMACVLATI CORDIS MARIAE ET CLARAE VIRGINIS".