Originally founded in September 1901, it is the oldest high school in Ventura County.

Over the next two decades, increasing enrollment necessitated a new facility, and under the leadership of Monsignor Anthony Jacobs and a generous land grant from Mr. and Mrs. Joseph Friedrich, the new Santa Clara High School opened on South Saviers Road in the spring of 1952.

[4] The program appeared in three straight state championship games (1989–1991), winning titles in 1989 and 1990.

[4] Twenty years later, and just three months after Cvijanovich's death, the Saints won a CIF-SS championship in 2019 under Bobby Tenorio.

[5] The Santa Clara boys' soccer team won its first CIF-SS championship in 2017.