[2] Villanova Preparatory School was established in 1924 at the request of Archbishop John Cantwell, the first head of the Roman Catholic Archdiocese of Los Angeles.

Each year, Clare Boothe Luce Program members participate in educational field trips such as to the Catalina Island Marine Institute and Santa Clara University's School of Engineering Maker Lab.

Additionally, Clare Boothe Luce members lead an annual STEM workshop for middle school students in the region, exploring the areas of environmental science, engineering, coding, robotics, biology, and chemistry.

The exercise is intended to instill in every student the school's core values of "truth, community, and love" while developing the leadership skills of seniors who lead each tribe.

[7] Villanova Prep defeated Chaffey High School 75-69 in overtime on February 25, 2022 to win its first-ever CIF-Southern Section Boys' Basketball Championship.

[10] In early 2006, it was discovered that the headmaster had hired a Latin teacher, Shannon McCreery, who had been convicted of second degree murder for assisting in his father's suicide in 1996.