Santa Croce is a Roman Catholic church located on Corso Vittorio Emanuele 178 in Padua, Veneto region, Italy.

The commission to build the present Rococo style church was given to a lay brother of the order, Francesco Vecelli (1695–1759).

The façade was designed to be a monument at the end of the Borgo Santa Croce, running from the Prato della Valle to the outer wall.

The church has four altarpieces by Giovanni Battista Mariotti (1690–1748), including depicting the founder of the Somaschi order San Girolamo Miani praying in a grotto.

[2] Cleric Somascan entrusted the large ceiling fresco, depicting the Exaltation of the Cross, and the oval dome of the presbytery to the Venetian Nicolo Baldassini.

The location of the paintings was altered with the arrival of the early 800 Salus Populi Patavini, venerated seventeenth-century wooden statue of Our Lady of Health, coming from the oratory and linked to the plague that struck the city in the seventeenth century.

The interior was frescoed circa 1537 with biblical scenes; the works have been attributed to Girolamo Dal Santo, Domenico Campagnola, Stefano Dall'Arzere, and others.