Santa Cruz is a corregimiento in Renacimiento District, Chiriquí Province, Panama.

It has a land area of 59.8 square kilometres (23.1 sq mi) and had a population of 1,904 as of 2010, giving it a population density of 31.8 inhabitants per square kilometre (82/sq mi).

[1] Its population as of 1990 was 2,859; its population as of 2000 was 2,785.

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