Santa Cruz is a municipality in the state of Rio Grande do Norte in the Northeast region of Brazil.

The area of the municipality of Santa Cruz was originally inhabited by the current Tapuia indigenous peoples.

24, dated 27 March, elevates the village to the status of district, with the name “Santa Cruz da Ribeira do Trairi”.

On the 30th of 1914, the state law 372, the village is inferior to the condition of city, having its name changed to «Santa Cruz».

In November 2007, on Monte Carmelo, construction began on a statue dedicated to the patron saint of the municipality, Santa Rita de Cássia.