Santa Cruz is a province in the Cajamarca Region of Peru, with its capital at Santa Cruz de Succhabamba.

The province of Santa Cruz's land area is 1,423 km2, 4.2% of the total of the Cajamarca Region.

Its lowest elevation is in the Saña River, near the small village of Pan de Azucar, 265 meters above sea level, and highest in the Cerro Cimarrones, 3,600 meters above sea level, south of the town of Pulán.

It is bounded to the North by Chota, to the East by Hualgayoc and Chota, to the South by San Miguel, and to the West by Lambayeque.

The province is divided into eleven districts: