Santa Cruz Zenzontepec is a town and municipality in Oaxaca in south-western Mexico.

The terrain is rugged, in the southern edge of the Sierra Madre del Sur.

Fauna include mountain lion, tiger, wild boar, deer, badger, opossum, fox, armadillo, squirrel, raccoon, skunk and bats.

The houses typically have cement floors, mud adobe walls and galvanized steel or tile roofs.

The majority of the population is engaged in agriculture, planting corn, beans and vegetables at the family level.