Santiago Amoltepec is a town and municipality in the state of Oaxaca in south-western Mexico.

The municipality covers an area of 142.99 km².

It is part of the Sola de Vega District in the Sierra Sur Region.

As of 2005, the municipality has a total population of 11,113.

[1] This article about a location in the Mexican state of Oaxaca is a stub.