Santa Fe is part of the traditional downtown area where Bogotá was founded by Gonzalo Jiménez de Quesada on August 6, 1538.

Santa Fe hosts several key business districts in Bogotá, and is served by Carrera Séptima, one of the city's major thoroughfares.

The locality is home to many of Bogotá's skyscrapers, including the International Center and the financial district along Avenida Jiménez.

Santa Fe also includes a rural area in the Eastern Hills where Monserrate and Guadalupe are prominent landmarks.

Santa Fe is primarily a commercial area, featuring a mix of small factories, service companies, and financial businesses.

TransMilenio operates along several key routes in Santa Fe: Additionally, since 1926, a funicular and an aerial tramway, have been available for ascending Monserrate.